Polysaccharides are underexploited marine bioresources and a source of natural ingredients for functional foods. Cardioprotective property of polysaccharides derived from marine algae possess good nutrient and medicinal benefits and could be used as an alternative source of dietary fibre. Bioactive sulphated polysaccharides are the main components of soluble fibre in marine algae, hence making it a valuable source. This review gives an overview of the cardioprotective properties of polysaccharides derived from marine algae. Recent studies have provided evidence that polysaccharides (chitin and fucoidan) from marine algae can play a vital role in cardioprotective activity. Further research work, especially clinical studies, are needed in order to gain a better knowledge of the structure–function relationship whereby these polysaccharides can exert potent cardioprotective activities at safe levels.