Tourism has the potential to be used as a positive tool for growth in developing nations. In order to gain the most benefit from tourism, planning and management is vital for successful tourism destination development and the attainment of conservation goals. This process should involve all stakeholders who might be affected by tourism and associated developments. In order for collaboration to be effective, there are certain social aspects that need to exist in stakeholder relationships such as open communication, transparency, and trust. Research has shown that these social variables are vital for the successful collaborative management of natural resources, and as such are important to the health of social and ecological systems upon which the future of tourism depends. This article investigates stakeholder relations and how these have influenced the Mnemba Island Marine Conservation Area in Zanzibar, Tanzania. Findings suggest a lack of structure in the working relationships of key stakeholders. As a result, these relationships are strained. Despite the importance of formal agreements and structured relations, these have been difficult to implement due to stakeholder conflict over resource control. Social variables (e.g., trust, transparency) shaping stakeholder relations had a largely negative impact on the health of social and ecological systems. Suggestions for a more detailed investigation into the complexities, challenges, and possibilities for stakeholder working relationships in the Mnemba Island Marine Conservation Area are provided