Plant and animal derived products are the main ingredients currently used by the feed industry to produce concentrate feed. There is a need of novel feed ingredients to meet the demand of high quality products by the aquaculture, ruminant and swine production systems, together with the challenge of implementing new sustainable and environmentally friendly processes and ingredients demanded by the modern society. Macroalgae are a large and diverse group of marine organisms that are able to produce a wide range of compounds with unique biological properties. This chapter discusses the incorporation of macroalgae or macroalgal derived ingredients as a source of both macro-nutrients (i.e. proteins, polysaccharides and fatty acids) and micro-nutrients (i.e. minerals and pigments) for animal feed production. The biological health benefits of the macroalgal ingredients beyond basic nutrition for the development of functional feed in the aquaculture, the ruminant and the swine sectors are also discussed together with the industrial challenges of its application.