The search of sustainable and environmentally friendly alternatives to obtain compounds for different industrial sectors has grown exponentially. Following the principles of biorefinery and circular bioeconomy, processes in which the use of natural resources such as macroalgae biomass is prioritized are required. This review focuses on a description of the relevance, application and engineering platforms of hydrothermal systems and the operational conditions depending on the target as an innovative technology and bio-based solution for macroalgae fractionation in order to recover profitable products for industries and investors. In this sense, hydrothermal treatments represent a promising alternative for obtaining different high value-added compounds from this biomass; since, the different variations in terms of operating conditions, gives great versatility to this technology compared to other types of processing, allowing it to be adapted depending on the objective, whether it is working under sub/super critical conditions, thus expanding its field of application.