The aim of this chapter is to present a comprehensive overview of integrated bio-oxycombustion systems with photobioreactors. Divided into seven distinct topics, the chapter discusses issues related to fundamentals of oxycom- bustion, the operational implications for oxycombustion-enhanced performance, oxygen produced by photosynthesis, volatile organic compounds as energy source, photobioreactors design, the process integration in bio-oxycombustion systems, and the hurdles of bio-oxycombustion technology, summarizing a range of useful strategies directed to the sustainable development of industrial combustion systems.