Analysis of Keystone Enzyme in Agar Hydrolysis Provides Insight into the Degradation of a Polysaccharide from Red Seaweeds

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Abstract: 

Background: The catalytic mechanism and substrate recognition required for cleavage of the -linkage in agarose are unclear.
Results: Structural analysis of a family 117 glycoside hydrolase details substrate recognition and supports an inverting mechanism. 

Conclusion: GH117 enzymes use substrate distortion and an unusual general acid for catalysis.
Significance: Microbes may utilize alternate strategies to catalyze the degradation of polysaccharides with unique structural characteristics

Author(s): 
Jan-Hendrik Hehemann
Leo Smyth
Anuj Yadav
David J. Vocadlo
Alisdair B. Boraston
Link / Ref: 
Pubmed
Attachment: 
PDF icon Analysis of Keystone Enzyme in Agar Hydrolysis Provides Insight into the Degradation (of a Polysaccharide from) Red Seaweeds.pdf
Article Source: 
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 287, Number 17
Category: 
Basic Biology
Seaweed composition
Uses of Seaweeds: Miscellaneous